HapOncoTM

肿瘤——临床用药基因检测

分子分型定位精准治疗

肿瘤是一种基因病,携带不同的基因突变决定患者适用不同的抗肿瘤药物。不同组织分型的肿瘤也可能携带相同的基因突变,
从而对相同的药物敏感。全面检测肿瘤患者携带的药物相关基因突变,可以对肿瘤进行分子分型,
并根据分子分型选择最适合的靶向/化疗药物,实现肿瘤的精准治疗。

分子分型定位精准治疗

全癌种451基因

肿瘤靶向用药及信号通路相关基因
ABL1BRIP1CRLF2FANCLGMEB1KMT2BMTUS1PIK3CGRECQLSPOP
ACTL6ABTKCSF1RFAT1GNA11KMT2CMUTYHPIK3R1RECQL4SRC
ADH1BBUB1CSF3RFBXW7GNAQKMT2DMYCPIK3R2RELSRD5A2
AKT1CADM2CTCFFGF1GNASKRASMYCLPIM1RETSRSF2
AKT2CALRCTNNB1FGF10GREM1KRT14MYCNPLAURRHEBSTAG2
AKT3CAMTA1CXCR4FGF2HFE2KRT15MYD88PLIN2RHOASTAT3
ALDH2CAPN2DDR2FGF23HGFKRT5MYOD1PMS1RICTORSTK11
ALKCARD11DDX3XFGF3HIF1ALARP4NBNPMS2RIF1SUZ12
ANXA5CASP8DDX51FGF4HNF1ALATS1NF1POLD1RILPSYK
APCCBFBDICER1FGF5HNF1BLATS2NF2POLERIT1SYNE1
ARCBLDNMT3AFGF6HOXB13LBRNFE2L2PPIBRNASELTERT
ARAFCBLBEGFRFGF7HRASLRIG3NKX2-1PPP2R1ARNF43TET1
AREGCCL18ELAC2FGF8HSD17B3MAP2K1NOTCH1PPP2R2AROS1TET2
ARID1ACCND1EP300FGF9HSD3B2MAP2K2NOTCH2PRDM1RPS6KB1TGFBR2
ARID1BCCND2EPCAMFGFR1HSP90AA1MAP2K4NOTCH3PRKACBRUNX1TMEM127
ARID2CCND3EPHA3FGFR2IDH1MAP3K1NOVA1PRKAR1ASBDSTNFRSF19
ASNSCCNE1ERBB2FGFR3IDH2MAPK1NPM1PRKCISDHATNFSF8
ASPHCD274ERBB3FGFR4IFNL2MAPK3NRASPRSS1SDHAF2TOP1
ASXL1CD79AERBB4FHIFNLR1MAPKBP1NRG1PSME2SDHBTP53
ATMCD79BERCC1FLCNIGF1RMAXNSD1PTCH1SDHCTRAF1
ATRCDC73ERCC2FLT1IGF2MCL1NTRK1PTENSDHDTSC1
ATRXCDH1ERCC5FLT3IKZF1MDM2NTRK3PTNSELLTSC2
AURKACDK12EREGFLT4IL7RMDM4PAK1PTPN11SETBP1TSHR
AXIN2CDK4ERGFOXA1INPP4BMED12PALB2PTPRDSETD2U2AF1
B2MCDK6ESR1FOXK2JAK1MEF2BPALLDPTPRTSETD7UGT1A1
BAP1CDKN1AETV1FOXL2JAK2MEN1PARP1RAC1SF3B1VEGFA
BARD1CDKN1BETV4FOXM1JAK3METPAX3RAD21SH2B3VHL
BCL2CDKN1CETV6FOXP1JUNMITFPAX5RAD50SHOXWAS
BCL6CDKN2AEWSR1FOXP2KCNJ5MKI67PAX7RAD51SLX4WRN
BCORCDKN2BEXT1GAB2KDM5CMLH1PAX8RAD51BSMAD2WT1
BCORL1CDKN2CEXT2GATA1KDM6AMLH3PBRM1RAD51CSMAD3XPO1
BLMCEBPAEZH2GATA2KDRMPLPDGFRARAD51DSMAD4YAP1
BMPR1ACFDFAM175AGATA3KEAP1MRE11APDGFRBRAD54LSMARCA4YES1
BRAFCHD4FANCAGEMIN6KIF1BMSH2PDPK1RAF1SMARCB1ZBTB16
BRCA1CHEK1FANCBGEN1KITMSH3PGRRARASMOZNF367
BRCA2CHEK2FANCCGK5KLF4MSH6PIK3CARB1SOCS6ZNF717
BRD2CICFANCGGLIPR1KLLNMST1RPIK3CBRBM10SOX2
BRD4CREBBPFANCIGLRXKMT2AMTORPIK3CDRECKSPINK1
化疗位点或MSI区域
ABCB1ARMS2CYP19A1DHFRFCGR3AIGFBP3MTHFRSEMA3CSLC29A1TPMT
ABCC11BCL2L11CYP1A2DPYDFOLR3IL13NOS3SLC15A2SLC31A1TYMS
ABCC2BIRC3CYP1B1DSCAMGALNT14KITNR1I2SLC19A1SLC7A8VEGFC
ABCC4C8orf34CYP2C19DYNC2H1GGHLGR5NT5C2SLC22A2SLCO1B1XPC
ABCC5CDACYP2D6EDN1GSTA1LRP2OTOSSLC22A4SLCO1B3XRCC1
ABCG2CFHCYP3A4EGFGSTP1MGAT4ARGS5SLC22A5SOD2ZNF2
ADCY2CMPK1CYP3A5FCGR2AHTRA1MSH2RRM1SLC28A2TNF
病毒序列
HPVEBVHBVHCV





全癌种86基因

ABL1BRAFCYP1B1DSCAMFOLR3LGR5NRASPDGFRBSLC19A1TYMS
AKT1BRCA1CYP2C8EGFRIGFBP3LRP2NTRK1PIK3CASLC22A2UGT1A1
AKT2BRCA2CYP2D6ERBB2GALNT14MAP2K1NOS3PMS2SLC28A2VEGFA
ALKBCL2CYP3A4ENOSF1GGHMETNT5C2PTENSLC29A1XPC
APCCDK4C8orf34ERCC1GSTA1MLH1OTOSRETSLC31A1XRCC1
ABCB1CDK6CCND1FGFR1GSTP1MSH2P53RICTORSLCO1B3
ABCC11CDADDR2FGFR3KDRMSH6PALB2ROS1SOD2
ABCC5CMPK1DHFRFLT1KITMTORPARP1RRM1TSC1
ADCY2CYP19A1DPYDFLT3KRASMTHFRPDGFRASEMA3CTPMT
适用人群
1
初次诊断患者,进行肿瘤分子分型,指导治疗方案、提示预后等;
2
有靶向及化疗用药需求的实体肿瘤患者;
3
常规用药耐药或毒副作用无法耐受,寻找其他可能治疗方式的患者。
新鲜组织

新鲜组织

患者血液

患者血液

恶性积液

恶性积液

石蜡切片

石蜡切片

典型案例

通过阅读典型案例,您将获悉海普洛斯的具体服务内容和其价值所在。

阶段一

2015.12

病情:确诊肺腺癌晚期

检测结果:EML4-ALK 融合阳性

治疗方案:克唑替尼治疗

阶段二

2017.02

病情说明:颈部淋巴结复发

检测结果:EML4-ALK 融合阳性、ALK p.C1156Y 突变

治疗方案:艾乐替尼治疗

阶段三

2017.04

病情说明:颈部淋巴结复发

检测结果:EML4-ALK 融合阳性、ALK p.C1156Y 突变、ALK p.G1202R 突变

治疗方案:劳拉替尼治疗

阶段四

2017.06

病情稳定

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